Another Study that Doesn’t Show How Acupuncture Works

steven_novellaby via NeuroLogica Blog

The pattern is now quite familiar – a study looking at some physiological outcome while rats or mice are being jabbed with needles is breathlessly presented as, “finally we know how acupuncture works.” As is always the case, a closer look reveals that the study shows nothing of the sort.
electroacupuncture-ratThe current study making the rounds is, “Effects of Acupuncture, RU-486 on the Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Adult Male Rats.” We are told that acupuncture has the same effect as pain medication, but honestly I don’t see that anywhere in the study.
The study presents two experiments with rats in which there is a control group, a stress group, stress plus acupuncture, and stress plus sham acupuncture. The first thing to notice is that the rats were not actually getting acupuncture. They were getting the fiction known as “electroacupuncture.” Electroacupuncture is not a real thing – it’s just electrical stimulation through a needle which is called an acupuncture needle.
The authors claim that their results show that electroacupuncture (EA) at the St36 acupuncture point (which is behind the leg), but not sham EA on the back blunt the stress response as measured by cortisol levels, ACTH, and stress behavior in the rats.
acupuncture 835_225pxJust looking at the data itself, separate from the context of acupuncture, there are a few things to notice. The first is that the study is very small, with (in the first experiment) 7 rats in the control and stress groups, and 14 rats in the EA and sham EA groups. That’s not a lot of data points. There is no mention of blinding anywhere in the study. Unless everyone involved in those aspects of the study measuring outcomes were effectively blinded, I see no reason to take the results seriously.
Further, the results are completely unimpressive. The differences are slight. The researchers also pull a common statistical trick. They say, for example, that the difference between control and EA was statistically significant, while the difference between control and sham EA was not. However, they don’t tell us whether or not the difference between EA and sham EA was significant (and by looking at the data I would guess not).
acupucture_chinese_medicine_300pxIt is therefore not valid to conclude that there is a difference between EA and sham EA. This is a common statistical “mistake” researchers make, probably having something to do with the fact that it makes negative data look positive.
It is possible that this study tells us nothing at all. Given the small number of rats in the study, no documentation about blinding, and the unimpressive results, just a touch of researcher bias (exploiting those researcher degrees of freedom) is all that is necessary to get the graphs to look good enough to publish.
Therefore, regardless of the subject matter, these are preliminary results at best, and unimpressive preliminary results at that.
If we put these results into the context of acupuncture, we then have the equivalent of Bem’s psi research – unimpressive results used to support a massive claim.
Let’s be clear – acupuncture points are a complete fiction.

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