Tag Archives: New England Journal of Medicine

MSG and gluten intolerance: Is the nocebo effect to blame?

Gluten and MSG intolerance may be only in your head.
That’s nothing to be ashamed of.

By via Slate Magazine

msg noWhile living in China from 2003 to 2005, I often served as the designated translator for fellow expatriates. Whenever we ate out, this involved asking our server which menu items contained MSG. Invariably I was told that almost everything is made with weijing (“flavor essence”), including, on one occasion, the roast peanut appetizer my MSG-sensitive friends were snacking on as I made my inquiry.

After observing that no one reacted to the peanuts, I was inspired to conduct a simple (and admittedly unethical) experiment. One evening, instead of translating honestly, I told my companions at a large banquet that the kitchen had promised to avoid using MSG. Everyone thanked me and happily ate their meal, dish after poisoned dish.

An hour later? Two hours later? The next day? Nothing.

I repeated this experiment on multiple occasions, always with the same result. And yet foreigners living in China routinely complained of reactions to their food that included headaches, chest pain, and shortness of breath. Was there something about my presence that conferred temporary resistance to MSG? Or could it be that MSG sensitivity was only in their heads?

In April 1968, the New England Journal of Medicine published a letter by Robert Ho Man Kwok that described a strange set of symptoms: “Numbness at the back of the neck, gradually radiating to both arms and the back, general weakness and palpitation.” Stranger still was the fact that Dr. Kwok, himself a Chinese immigrant, typically noted the onset of these symptoms 20 minutes after eating at restaurants serving “Northern Chinese food.”

An editor at NEJM titled Kwok’s letter “Chinese-restaurant syndrome,” and thus began a minor epidemic. For countless sufferers, a mystery had been finally solved. “NO MSG” signs sprang up across the United States, and, eventually, the world. Study upon study confirmed the syndrome’s existence and speculated about the science underlying it.

But after reading some of these studies, even a layperson will start to get suspicious. Take the editorial note that precedes Russell S. Asnes’ article “Chinese Restaurant Syndrome in an Infant”:

“The evidence that this infant had the Chinese Restaurant syndrome may be only circumstantial. However, the description of the symptom is accurate as attested to by the Editor’s wife who suffers from the same malady. Incidentally, she remains a devotee of Chinese cuisine.”

Science, that sworn enemy of circumstantial evidence, marched on, and slowly but surely physiological explanations of Chinese restaurant syndrome began to lose credibility. Double-blinded studies failed to turn up evidence of a clinical condition. MSG, many people noted, appears in everything from sushi to Doritos. gluten-intolerantJournalists performed experiments similar to mine, their results echoing the consensus of professional scientists: In the overwhelming majority of cases, MSG sensitivity is a psychological phenomenon.

Despite this thorough debunking, a surprisingly large number of people—generally those who lived through the epidemic—still insist they are sensitive to MSG. Google around and you’ll turn up scores of alarmist websites, which tend to combine outdated research with anecdotal, indignant rebuttals of the current scientific wisdom: “How dare you suggest my MSG sensitivity is only in my head? Why, just the other day I went out for Chinese and forgot to ask about MSG. After 45 minutes I couldn’t breathe and my heart was racing.”

Occasionally, as with vaccines and climate change denial, alarmism veers into paranoia, yielding accusations that a shadowy East Asian cabal is paying off scientists and journalists to regurgitate their propaganda.

MORE . . .

%d bloggers like this: